Also known as Stenabolic, SR9009 has been developed by Scripps Research Institute under the leadership of professor Thomas Burris.
As mentioned beforehand, SR9009 is a synthetic Rev-Erb ligand, which is taken orally. This is a very unique compound. By stimulating the Rev-Erb protein, SR9009 has the ability to greatly influence a lot of regulatory mechanisms in the human body. For instance, it can affect the circadian rhythms, lipid and glucose metabolism, fat-storing cells, as well as macrophages. Hence, Stenabolic will allow the user to lose fat and drastically increase endurance, both of which are very desirable effects for an athlete.
By binding and activating the Rev-Erb protein, Stenabolic triggers a very wide range of processes in the body. The most prominent being the increase of mitochondria count in the muscles and an enhanced metabolism.
As a consequence of the increased number of mitochondria in the muscles, the user will notice a drastic improvement in endurance and muscle strength. In fact, the mice used in studies could run 50% more when they were administered with SR9009, both in terms of distance and time. This is possible due to the fact that these mitochondria are precisely the ones generating energy in the body. Besides, thanks to the increase in number of macrophages, defective mitochondria are removed from the muscles and replaced with new ones.
Furthermore, the change in metabolic rates increases energy expenditure by 5% even when the user is resting; hence, SR burns excess calories and doesn’t allow them to convert into fat. This, coupled with enhanced metabolism of glucose, helps effectively burn fat, which makes the body act is if it were in a constant state of exercise. To confirm this, we can see that according to studies, the activation of the Rev-Erb protein by Stenabolic leads to:
“….decreased lipogenesis and cholesterol/bile acid synthesis in the liver, increased lipid and glucose oxidation in the skeletal muscle, and decreased triglyceride synthesis and storage in the WAT.”
This means that less fat is stored, less cholesterol is developed by the liver, and more fat and glucose is burned in the muscles.
However, these are not the only positive health effects seen with stenabolic. In fact, in the studies carried out with this compound it was found that it will decrease:
- Plasma triglycerides by 12%
- Total cholesterol by 47%
- Plasma non-esterified fatty acids by 23%
- Plasma glucose by 19%
- Plasma insulin level by 35%
If that wasn’t enough, we need to mention that SR9009 will also decrease proinflammatory cytokine IL-6 by a whopping 72%, which will obviously be very beneficial for the reduction of inflammations.